Anti-Inflammatory Action
CBD activates CB2 receptors on immune cells to decrease pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) and reduce synovial inflammation. THCA acts as a potent PPARγ agonist, suppressing COX-2 expression and downregulating inflammatory mediators. Together, treated dogs experience significantly less joint pain and improved daily mobility in osteoarthritis.
Anti-Nausea Effects
CBD enhances serotonin 5-HT₁A receptor signalling to alleviate nausea in animal emesis models. THCA reduces nausea and vomiting through a CB1 receptor-mediated mechanism, shown to be more potent than THC at equivalent doses — without sedation or locomotor impairment. Both compounds provide non-sedating digestive comfort suitable for travel and motion sensitivity.
Cancer Support
CBD inhibits cancer cell proliferation, migration, and neovascularisation across multiple tumour lines, with pro-apoptotic and anti-metastatic effects. THCA shows anti-tumour promise via PPARγ-mediated pathways and demonstrates the highest binding affinity among cannabinoids to glucose-6-phosphate dehydrogenase, a cancer-promoting enzyme. Further veterinary clinical investigation is warranted.
Safety Profile
THCA is a non-psychoactive acidic cannabinoid with negligible CB1 receptor binding — plasma analysis confirms it does not convert to THC at therapeutic doses. CBD is a non-psychoactive neutral cannabinoid. Veterinary pharmacokinetic studies in dogs and cats confirm no behavioural signs of intoxication at therapeutic doses for either compound.
Seizure Control
CBD modulates neuronal excitability through GABAergic, serotonergic, and TRPV1 pathways to reduce seizure frequency. Veterinary clinical trials report a 24–33% decrease in epileptic episodes in dogs with drug-resistant epilepsy, without sedation. THCA contributes neuroprotective support through PPARγ-mediated pathways, with preliminary evidence suggesting anti-seizure potential.
Stress & Anxiety Management
CBD modulates stress-related neural pathways, with veterinary studies demonstrating reduced cortisol levels, lower aggression in shelter dogs, and decreased stress behaviours during separation and car travel. THCA may support stress management via neuroprotective PPARγ pathways. Appropriate dosing is critical for anxiolytic efficacy.
